AM25-SN-13-L - Update on the Use of Cryopreserved Platelets in Acute Surgical Settings

Sunday, October 26, 2025

2:30 PM - 3:30 PM PT

Location: 20D

Speaker(s)

Jose Cancelas, MD, PhD

Executive Director, Connell and O'Reilly Families Cell Manipulation Core Facility, Medical Oncology
Dana-Farber Cancer Institute
Boston, Massachusetts

Disclosure(s): No relevant disclosure to display
Glenn Whitman, MD (he/him/his)

Professor, Division of Cardiac Surgery, Co-Director, CVSICU, JHH Director, Cardiac Surgery Quality,JHHS
Johns Hopkins School of Medicine
Baltimore, Maryland

Disclosure(s): No relevant disclosure to display

Program Chair(s)

Claudia Cohn, MD, PhD (she/her/hers)

Professor of Laboratory Medicine and Pathology, Director, Blood Bank Laboratory
University of Minnesota
Minneapolis, Minnesota

Disclosure(s): No relevant disclosure to display

Proposed Session Description: This session will provide an update on the “Use of Cryopreserved Platelets in Acute Surgical Settings”. To provide context for this session, the first speaker will present an update on the basic science of platelet products used clinically including differences in manufacturing approaches and resulting product characteristics of cryopreserved platelets versus room temperature and cold stored platelets. The next speaker will present key results from a recently conducted Systematic Literature Review that will provide the audience with a evidence-based summary of outcome data relating to the clinical use of cryopreserved platelets in acute surgical settings with comparison to cold stored and room temperature platelets. Finally, the last speaker will present topline results from the CRYPTICS - NCT04709705 Phase 2/3 clinical trial supporting the first cryopreserved platelet product being developed for approved use in the US.

Learning Objectives:

Describe differences in the way cryopreserved platelets are manufactured, compare the resultant properties to liquid stored platelets and interpret the significance of these differences
Summarize key findings from the most recent findings of a Systematic Literature Review on the use of cryopreserved platelets in acute surgical bleeding settings
Review the topline results from the Phase 2/3 CRYPTICS clinical trial and report the key take-aways