AM25-TU-17-L - The Monocyte Monolayer Assay in Transfusion Medicine: Historical Insights and Clinical Applications

Proposed Session Description: The Monocyte Monolayer Assay (MMA) has emerged as a crucial tool in the assessment of red cell alloantibodies, significantly influencing transfusion decisions and facilitating advancements in immunohematology. This session will explore the origins and development of the MMA, a groundbreaking method pioneered by Dr. George Garratty and Sandy Nance.

Participants can expect a comprehensive exploration of the fundamental principles and methodology underlying the assay. We will showcase a selection of captivating and intricate case studies that illustrate the MMA’s specific utilization and its profound impact on patient clinical outcomes.
It appears that there may be some misunderstandings regarding the assay’s use and the associated logistics among the Transfusion Medicine community. We will address these gaps and discuss recent trends in MMA ordering practices, including how utilization has evolved over the past few years and which antibodies are most commonly evaluated.

Furthermore, the session will provide valuable insights for laboratory professionals and physicians, offering guidance on effectively integrating the MMA into complex transfusion challenges, ensuring better patient care and decision-making. We will address recent trends in MMA ordering practices, including how utilization has evolved over the past few years and which antibodies are most commonly evaluated. Additionally, the session will discuss when the MMA is recommended, what collaboration looks like across hospitals and reference labs, and how laboratory operations can support its implementation in day-to-day practice.